Fragile X Syndrome and Autism at the Intersection of Genetic and Neural Networks

Matthew K Belmonte and Thomas Bourgeron

Nature Neuroscience 9(10):1221-1225 (2006).

ABSTRACT

Autism, an entirely behavioural diagnosis with no largely understood ætiologies and no population-wide biomarkers, contrasts with fragile X syndrome (FXS), a single-gene disorder with definite alterations of gene expression and neuronal morphology. Nevertheless, the behavioural overlap between autism and FXS suggests some overlapping mechanisms. Understanding how the single-gene alteration in FXS plays out within complex genetic and neural network processes may suggest targets for autism research and illustrate strategies for relating autism to more singular genetic syndromes.

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CITED IN MY OTHER PUBLICATIONS:

  1. Baron-Cohen S, Golan O, Chakrabarti B, Belmonte MK. Social cognition and autism spectrum conditions. In: Social Cognition and Developmental Psychopathology (C Sharp, P Fonagy, I Goodyer, eds.), pp 29-56. Oxford: Oxford University Press (4 September 2008).