Autism: A Window onto the Development of the Social and the Analytic Brain

Simon Baron-Cohen and Matthew K Belmonte

Annual Review of Neuroscience 28:109-126 (2005).

ABSTRACT
Although the neurobiological understanding of autism has been increasing exponentially, the diagnosis of autism spectrum conditions still rests entirely on behavioural criteria. Autism is therefore most productively approached by a combination of biological and psychological theory. Psychologically, autism's triad of behavioural abnormalities in social function, communication, and restricted and repetitive behaviours and interests can be explained by an impaired capacity for empathizing, or modelling the mental states governing the behaviour of people, along with a superior capacity for systemizing, or inferring the rules governing the behaviour of objects. This empathizing-systemizing theory explains other psychological models such as impairments of executive function or central coherence, and may have a neurobiological basis in abnormally low activity of brain regions subserving social cognition along with abnormally high activity of regions subserving lower-level, perceptual processing, a pattern that may result from a skewed balance of local versus long-range functional connectivity.

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CITED IN PUBLICATIONS BY OTHERS:

  1. Meyer-Lindenberg A, Mervis CB, Berman KF. Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour. Nature Reviews Neuroscience 7(5):380-393 (May 2006).
  2. Kwon C, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF. Pten regulates neuronal arborization and social interaction in mice. Neuron 50(3):377-388 (4 May 2006).
  3. Tomlin D, Kayali MA, King-Casas B, Anen C, Camerer CF, Quartz SR, Montague PR. Agent-specific responses in the cingulate cortex during economic exchanges. Science 312(5776):1047-1050 (19 May 2006).
  4. Behrmann M, Thomas C, Humphreys K. Seeing it differently: visual processing in autism. Trends in Cognitive Sciences 10(6):258-264 (June 2006).
  5. Baron-Cohen S, Klin A. What's so special about Asperger syndrome? Brain and Cognition 61(1):1-4 (June 2006).
  6. Golan O, Baron-Cohen S, Hill JJ, Golan Y. The “Reading the Mind in Films” task: complex emotion recognition in adults with and without autism spectrum conditions. Social Neuroscience 1(2):111-123 (June 2006).
  7. Moldin SO, Rubenstein JLR, Hyman SE. Can autism speak to neuroscience? Journal of Neuroscience 26(26):6893-6896 (28 June 2006).
  8. Badcock C, Crespi B. Imbalanced genomic imprinting in brain development: an evolutionary basis for the ætiology of autism. Journal of Evolutionary Biology 19(4):1007-1032 (July 2006).
  9. Gyseler D. The problematic case of neuropedagogics. Zeitschrift fur Padagogik 52(4):555-570 (July-August 2006).
  10. Klimkeit EI, Bradshaw JL. Heritable mental disorders: you can't choose your relatives, but it is they who may really count. Behavioral and Brain Sciences 29(4):414-415 (August 2006).
  11. Shinohe A, Hashimoto K, Nakamura K, Tsujii M, Iwata Y, Tsuchiya KJ, Sekine Y, Suda S, Suzuki K, Sugihara GI, Matsuzaki H, Minabe Y, Suglyama T, Kawai M, Yo M, Takei N, Mori N. Increased serum levels of glutamate in adult patients with autism. Progress in Neuro-psychopharmacology and Biological Psychiatry 30(8):1472-1477 (30 December 2006).
  12. Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suzuki K, Minabe Y, Takei N, Yo M, Mori N. Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Progress in Neuro-psychopharmacology and Biological Psychiatry 30(8):1529-1531 (30 December 2006).
  13. Gray PO. Psychology. New York: Worth Publishers (2007), p 585.
  14. Carter CS. Sex differences in oxytocin and vasopressin: implications for autism spectrum disorders? Behavioural Brain Research 176(1):170-186 (10 January 2007).
  15. Okada K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Suzuki K, Sughara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N. Decreased serum levels of transforming growth factor β1 in patients with autism. Progress in Neuro-psychopharmacology and Biological Psychiatry 31(1):187-190 (30 January 2007).
  16. Fonagy P, Gergely G, Target M. The parent-infant dyad and the construction of the subjective self. Journal of Child Psychology and Psychiatry 48(3-4):288-328 (March-April 2007).
  17. Sugihara G, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suzuki K, Suda S, Matsuzaki H, Kawai M, Minabe Y, Yagi A, Takei N, Sugiyama T, Mori N. Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry 31(2):412-415 (30 March 2007).
  18. Yeates KO, Bigler ED, Dennis M, Gerhardt CA, Rubin KH, Stancin T, Taylor HG, Vannatta K. Social outcomes in childhood brain disorder: a heuristic integration of social neuroscience and developmental psychology. Psychological Bulletin 133(3):535-556 (May 2007).
  19. Gabriels RL. Understanding Behavioral and emotional issues in autism. In: Growing Up with Autism: Working with School-Age Children and Adolescents (RL Gabriels & DE Hill, eds.), pp 3-38. New York: Guilford Press (May 2007).
  20. Golan O, LaCava PG, Baron-Cohen S. Assistive technology as an aid in reducing social impairments in autism. In: Growing Up with Autism: Working with School-Age Children and Adolescents (RL Gabriels & DE Hill, eds.), pp 124-144. New York: Guilford Press (May 2007).
  21. Hannan AJ. Brain phylogeny, ontogeny and dysfunction: integrating evolutionary, developmental and clinical perspectives in cognitive neuroscience. Acta Neuropsychiatrica 19(3):149-158 (June 2007).
  22. Johnson KA, Robertson IH, Kelly SP, Silk TJ, Barry E, Daibhis A, Watchorn A, Keavey M, Fitzgerald M, Gallagher L, Gill M, Bellgrove MA. Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention. Neuropsychologia 45(10):2234-2245 (2007).
  23. Tommerdahl M, Tannan V, Cascio CJ, Baranek GT, Whitsel BL. Vibrotactile adaptation fails to enhance spatial localization in adults with autism. Brain Research 1154:116-123 (18 June 2007).
  24. Hayden BY, Parikh PC, Deaner RO, Platt ML. Economic principles motivating social attention in humans. Proceedings of the Royal Society B 274(1619):1751-1756 (22 July 2007).
  25. Neeley ES, Bigler ED, Krasny L, Ozonoff S, McMahon W, Lainhart JE. Quantitative temporal lobe differences: autism distinguished from controls using classification and regression tree analysis. Brain and Development 29(7):389-399 (August 2007).
  26. Hughes JR. Autism: The first firm finding = underconnectivity? Epilepsy and Behavior 11(1):20-24 (August 2007).
  27. Suzuki K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N. Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism. Biological Psychiatry 62(3):267-269 (1 August 2007).
  28. Lee JE, Bigler ED, Alexander AL, Lazar M, DuBray MB, Chung MK, Johnson M, Morgan J, Miller JN, McMahon WM, Luh J, Jeong E, Lainhart JE. Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism. Neuroscience Letters 424(2):127-132 (7 September 2007).
  29. South M, Ozonoff S, Mcmahon WM. The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum. Autism 11(5):437-451 (September 2007).
  30. Geschwind D. Autism: searching for coherence. Biological Psychiatry 62(9):949-950 (1 November 2007).
  31. Tsuchiya KJ, Hashimoto K, Iwata Y, Tsujii M, Sekine Y, Sugihara G, Matsuzaki H, Suda S, Kawai M, Nakamura K, Minabe Y, Yagi A, Iyo M, Takei N, Mori N. Decreased serum levels of platelet-endothelial adhesion molecule (PECAM-1) in subjects with high-functioning autism: a negative correlation with head circumference at birth. Biological Psychiatry 62(9):1056-1058 (1 November 2007).
  32. Goursaud A, Bachevalier J. The origin of developmental psychopathologies: insights from nonhuman primate studies. In: Primate Models of Children’s Health and Developmental Disabilities (Burbacher TM, Sackett GP, Grant KS, eds.), pp 11-44. New York: Academic Press (13 November 2007, c2008).
  33. Badaruddin DH, Andrews GL, Bolte S, Schilmoeller KJ, Schilmoeller G, Paul LK, Brown, WS. Social and behavioral problems of children with agenesis of the corpus callosum. Child Psychiatry and Human Development 38(4):287-302 (December 2007).
  34. Bor D, Billington J, Baron-Cohen S. Savant memory for digits in a case of synæsthesia and Asperger syndrome is related to hyperactivity in the lateral prefrontal cortex. Neurocase 13(5-6):311-319 (October-December 2007).
  35. Ruggieri V, Arberas C. Trastornos generalizados del desarrollo. Aspectos clínicos y genéticos. Medicina (Buenos Aires) 67(6):569-585 (2007).
  36. Pizzamiglio MR, Piccardi L, Zotti A. Lo Spettro Autistico: Definizione, valuatione e riabilitazione in neuropsicologia. Milano: FrancoAngeli (2007), p 63.
  37. Young LJ, Carter CS. Sex differences in affiliative behavior and social bonding. In: Sex Differences in the Brain: From Genes to Behavior (JB Becker, KJ Berkley, N Geary, E Hampson, JP Herman, EA Young, eds.), pp 139-153. New York: Oxford University Press, 6 December 2007 (c2008).
  38. Pinel JPJ. Biopsychology 7/e. Boston: Allyn & Bacon (2008), p 230.
  39. Remschmidt H. Autismus. In: Entwicklungspsychiatrie: Biopsychologische Grundlagen und die Entwicklung psychischer Störungen (B Herpertz-Dahlmann, F Resch, M Schulte-Markwort, A Warnke, eds.), pp 600-625. Stuttgart: Schattauer (2008).
  40. Caldwell HK, Lee HJ, Macbeth AH, Young WS. Vasopressin: behavioral roles of an “original” neuropeptide. Progress in Neurobiology 84(1):1-24 (January 2008).
  41. Kilpinen H, Ylisaukko-Oja T, Hennah W, Palo OM, Varilo T, Vanhala R, Wendt TNV, von Wendt L, Paunio T, Peltonen L. Association of DISC1 with autism and Asperger syndrome. Molecular Psychiatry 13(2):187-196 (February 2008).
  42. Braeutigam S, Swithenby SJ, Bailey AJ. Contextual integration the unusual way: a magnetoencephalographic study of responses to semantic violation in individuals with autism spectrum disorders. European Journal of Neuroscience 27(4):1026-1036 (February 2008).
  43. Stein MB, Stein DJ. Social anxiety disorder. Lancet 371(9618):1115-1125 (March-April 2008).
  44. Lepagnol-Bestel AM, Maussion G, Boda B, Cardona A, Iwayama Y, Delezoide AL, Moalic JM, Muller D, Dean B, Yoshikawa T, Gorwood P, Buxbaum JD, Ramoz N, Simonneau M. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. Molecular Psychiatry 13(4):385-397 (April 2008).
  45. Brodkin ES. Social behavior phenotypes in Fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (2008). Behavioral Neuroscience 122(2):483-489 (April 2008).
  46. Hardy-Vallee B, Thagard P. How to play the ultimatum game: an engineering approach to metanormativity. Philosophical Psychology 21(2):173-192 (2008).
  47. Buccino G, Amore M. Mirror neurons and the understanding of behavioural symptoms in psychiatric disorders. Current Opinion in Psychiatry 21(3):281-285 (May 2008).
  48. Schenkel LS, Marlow-O'Connor M, Moss M, Sweeney JA, Pavuluri MN. Theory of mind and social inference in children and adolescents with bipolar disorder. Psychological Medicine 38(6):791-800 (June 2008).
  49. Crespi B, Badcock C. Psychosis and autism as diametrical disorders of the social brain. Behavioral and Brain Sciences 31(3):241-261 (June 2008).
  50. Reeder GD. Perceptions of goals and motives in romantic relationships. In: Handbook of Relationship Initiation (S Sprecher, A Wenzel, J Harvey, eds.), pp 499-514. New York: Taylor & Francis (11 June 2008), p 500.
  51. Higashida H, Jin D, Liu H, Lopatina O, Yokoyama S, Koizumi K, Hashii M, Islam MS, Hayashi K, Munesue T. Social memory, maternal care, and oxytocin secretion, but not vasopressin release, require CD38 in mice. In: Neurobiology of the Parental Brain (RS Bridges, ed.), pp 361-375. San Diego: Academic Press (1 July 2008).
  52. Allan AM, Liang XM, Luo YP, Pak CH, Li XK, Szulwach KE, Chen DH, Jin P, Zhao XY. The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Human Molecular Genetics 17(13):2047-2057 (1 July 2008).
  53. Higashida H, Jin D, Liu H, Lopatina O, Yokoyama S, Koizumi K, Hashii M, Islam S, Hayashi K, Munesue T. Social memory, maternal care, and oxytocin secretion, but not vasopressin release, require CD38 in mice. In: Neurobiology of the Parental Brain (Bridges RS, ed.), pp 361-376. Burlington, Massachusetts: Academic Press (29 July 2008).
  54. Golan O, Baron-Cohen S, Golan Y. The ‘reading the mind in films’ task [child version]: complex emotion and mental state recognition in children with and without autism spectrum conditions. Journal of Autism and Developmental Disorders 38(8):1534-1541 (September 2008).
  55. Baron-Cohen S, Chakrabarti B. Social neuroscience. In: Child Neuropsychology: Concepts, Theory, and Practice (Reed J & Rogers JW, eds.), pp 316-339. Oxford: Blackwell (7 October 2008).
  56. Baron-Cohen C, Chakrabarti B. Social neuroscience. In: Child Neuropsychology: Concepts, Theory, and Practice (J Reed & J Warner-Rogers, eds.), pp 316-339. Chichester: Wiley-Blackwell (13 October 2008).
  57. De Martino B, Harrison NA, Knafo S, Bird G, Dolan RJ. Explaining enhanced logical consistency during decision making in autism. Journal of Neuroscience 28(42):10746-10750 (15 October 2008).
  58. Nestler EJ, Hyman SE, Malenka RC. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience 2/e. Columbus, Ohio: McGraw-Hill (27 October 2008, c2009).
  59. Walsh CA, Morrow EM, Rubenstein JLR. Autism and brain development. Cell 135(3):396-400 (31 October 2008).
  60. Shaner A, Miller G, Mintz J. Autism as the low-fitness extreme of a parentally selected fitness indicator. Human Nature 19(4):389-413 (December 2008).
  61. Dichter GS, Belger A. Atypical modulation of cognitive control by arousal in autism. Psychiatry Research: Neuroimaging 164(3):185-197 (30 December 2008).
  62. Kusenda M, Sebat J. The role of rare structural variants in the genetics of autism spectrum disorders. Cytogenetic and Genome Research 123(1-4):36-43 (2008).
  63. Walter E, Dassonville P, Bochsler TM. A specific autistic trait that modulates visuospatial illusion susceptibility. Journal of Autism and Developmental Disorders 39(2):339-349 (February 2009).
  64. Gunji A, Inagaki M, Inoue Y, Takeshima Y, Kaga M. Event-related potentials of self-face recognition in children with pervasive developmental disorders. Brain and Development 31(2):139-147 (February 2009).
  65. Yamakawa Y, Kanai R, Matsumura M, Naito E. Social distance evaluation in human parietal cortex. PLoS ONE 4(2):e4360 (10 February 2009).
  66. Chen Y, Rodgers J, McConachie H. Restricted and repetitive behaviours, sensory processing and cognitive style in children with autism spectrum disorders. Journal of Autism and Developmental Disorders 39(4):635-642 (April 2009).
  67. Annaz D, Karmiloff-Smith A, Johnson MH, Thomas MSC. A cross-syndrome study of the development of holistic face recognition in children with autism, Down syndrome, and Williams syndrome. Journal of Experimental Child Psychology 102(4):456-486 (April 2009).
  68. von Hofsten C, Uhlig H, Adell M, Kochukhova O. How children with autism look at events. Research in Autism Spectrum Disorders 3(2):556-569 (April-June 2009).
  69. Corbett BA, Constantine LJ, Hendren R, Rocke D, Ozonoff S. Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Research 166(2-3):210-222 (30 April 2009).
  70. Fonagy P, Twemlow SW, Vernberg EM, Nelson JM, Dill EJ, Little TD, Sargent JA. A cluster randomized controlled trial of child-focused psychiatric consultation and a school systems-focused intervention to reduce aggression. Journal of Child Psychology and Psychiatry 50(5):607-616 (May 2009).
  71. Geschwind DH. Advances in autism. Annual Review of Medicine 60:367-380 (2009).
  72. Hoch RV, Rubenstein JLR, Pleasure S. Genes and signaling events that establish regional patterning of the mammalian forebrain. Seminars in Cell and Developmental Biology 20(4):378-386 (June 2009).
  73. Corina D, Singleton J. Developmental social cognitive neuroscience: insights from deafness. Child Development 80(4):952-967 (July-August 2009).
  74. Kolb B, Whishaw IQ. Fundamental of Human Neuropsychology 6/e. New York: Worth Publishers (2009).
  75. Hasson U, Avidan G, Gelbard H, Vallines I, Harel M, Minshew N, Behrmann M. Shared and idiosyncratic cortical activation patterns in autism revealed under continuous real-life viewing conditions. Autism Research 2(4):220-231 (August 2009).
  76. Yoder P, Stone WL, Walden T, Malesa E. Predicting social impairment and ASD diagnosis in younger siblings of children with autism spectrum disorder. Journal of Autism and Developmental Disorders 39(10):1381-1391 (October 2009).
  77. Simmons DR, Robertson AE, McKay LS, Toal E, McAleer P, Pollick FE. Vision in autism spectrum disorders. Vision Research 49(22):2705-2739 (10 November 2009).
  78. Kelemenova S, Ostatnikova D. Neuroendocrine pathways altered in autism. Special role of reelin. Neuroendocrinology Letters 30(4):429-436 (2009).
  79. Oldershaw A, Hambrook D, Tchanturia K, Treasure J, Schmidt U. Emotional theory of mind and emotional awareness in recovered anorexia nervosa patients. Psychosomatic Medicine 72(1):73-79 (January 2010).
  80. Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N. Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry 34(1):154-158 (1 February 2010).
  81. Dziobek I, Bahnemann M, Convit A, Heekeren HR. The role of the fusiform-amygdala system in the pathophysiology of autism. Archives of General Psychiatry 67(4):397-405 (April 2010).
  82. Cheng Y, Chou K, Chen I, Fan Y, Decety J, Lin C. Atypical development of white matter microstructure in adolescents with autism spectrum disorders. NeuroImage 50(3):873-882 (15 April 2010).
  83. Meguid N, Fahim C, Yoon U, Nashaat NH, Ibrahim AS, Mancini-Marie A, Brandner C, Evans AC. Brain morphology in autism and fragile X syndrome correlates with social IQ: first report from the Canadian-Swiss-Egyptian Neurodevelopmental Study. Journal of Child Neurology 25(5):599-608 (May 2010).
  84. Bigler ED, Abildskov TJ, Petrie JA, Johnson M, Lange N, Chipman J, Lu J, McMahon W, Lainhart JE. Volumetric and voxel-based morphometry findings in autism subjects with and without macrocephaly. Developmental Neuropsychology 35(3):278-295 (2010).
  85. Hyman SE. The diagnosis of mental disorders: the problem of reification. Annual Review of Clinical Psychology 6(6):155-179 (2010).
  86. Gould TJ. A comparison of mechanism underlying the CS-US association and the CS-nothing association. In: Latent Inhibition: Cognition, Neuroscience and Applications to Schizophrenia (Lubow RE & Weiner I, eds.), pp 252-266. Cambridge: Cambridge University Press (14 June 2010).
  87. Yoshida W, Dziobek I, Kliemann D, Heekeren HR, Friston KJ, Dolan RJ. Cooperation and heterogeneity of the autistic mind. Journal of Neuroscience 30(26):8815-8818 (30 June 2010).
  88. Glaser B, Debbane M, Ottet MC, Vuilleumier P, Zesiger P, Antonarakis SE, Eliez S. Eye gaze during face processing in children and adolescents with 22q11.2 deletion syndrome. Journal of the American Academy of Child and Adolescent Psychiatry 49(7):665-674 (July 2010).
  89. Dichter GS, Benning SD, Holtzclaw TN, Bodfish JW. Affective modulation of the startle eyeblink and postauricular reflexes in autism spectrum disorder. Journal of Autism and Developmental Disorders 40(7):858-869 (July 2010).
  90. Paul LK, Corsello C, Tranel D, Adolphs R. TPH2 polymorphisms and expression in Prader-Willi syndrome subjects with differing genetic subtypes. Journal of Neurodevelopmental Disorders 2(3):165-173 (September 2010).
  91. Townsend J, Westerfield M. Autism and Asperger’s syndrome: a cognitive neuroscience perspective. In: Handbook of Medical Neuropsychology (Armstrong CL & Morrow L, eds.), pp 165-191. New York: Springer (25 August 2010).
  92. Kishida KT, King-Casas B, Montague PR. Neuroeconomic approaches to mental disorders. Neuron 67(4):543-554 (26 August 2010).
  93. Perkins T, Stokes M, McGillivray J, Bittar R. Mirror neuron dysfunction in autism spectrum disorders. Journal of Clinical Neuroscience 17(10):1239-1243 (October 2010).
  94. Lai MC, Lombardo MV, Chakrabarti B, Sadek SA, Pasco G, Wheelwright SJ, Bullmore ET, Baron-Cohen S, Suckling J. A shift to randomness of brain oscillations in people with autism. Biological Psychiatry 68(12):1092-1099 (15 December 2010).
  95. Freberg LA. Discovering Biological Psychology 2/e. Belmont, California: Wadsworth (2010).
  96. Oldershaw A, Hambrook D, Stahl D, Tchanturia K, Treasure J, Schmidt U. The socio-emotional processing stream in Anorexia Nervosa. Neuroscience and Biobehavioral Reviews 35(3):970-988 (January 2011).
  97. Weinger PM, Depue RA. Remediation of deficits in recognition of facial emotions in children with autism spectrum disorders. Child and Family Behavior Therapy 33(1):20-31 (January 2011).
  98. Chou K, Cheng Y, Chen I, Lin C, Chu W. Sex-linked white matter microstructure of the social and analytic brain. NeuroImage 54(1):725-733 (1 January 2011).
  99. Pellicano E, Smith AD, Cristino F, Hood BM, Briscoe J, Gilchrist ID. Children with autism are neither systematic nor optimal foragers. Proceedings of the National Academy of Sciences of the United States of America 108(1):421-426 (4 January 2011).
  100. Yoshida K, Saito N, Iriki A, Isoda M. Representation of others’ action by neurons in monkey medial frontal cortex. Current Biology 21(3):249-253 (8 February 2011).
  101. Braeutigam S, Swithenby S, Bailey A. Magnetoencephalography (MEG) as a tool to investigate the neurophysiology of autism. In: Researching the Autism Spectrum: Contemporary Perspectives (Roth I & Rezaie P, eds.), pp 156-175. Cambridge: Cambridge University Press (14 February 2011).
  102. Pellicano E. Psychological models of autism: an overview. In: Researching the Autism Spectrum: Contemporary Perspectives (Roth I & Rezaie P, eds.), pp 219-265. Cambridge: Cambridge University Press (14 February 2011).
  103. Lo Y, Soong W, Gau SS, Wu Y, Lai M, Yeh F, Chiang W, Kuo L, Jaw F, Tseng WI. The loss of asymmetry and reduced interhemispheric connectivity in adolescents with autism: a study using diffusion spectrum imaging tractography. Psychiatry Research: Neuroimaging 192(1):60-66 (30 April 2011).
  104. Zheng F, Wang L, Jia M, Yue W, Ruan Y, Lu T, Liu J, Li J, Zhang D. Evidence for association between Disrupted-in-schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study. Behavioral and Brain Functions 7:14 (15 May 2011).
  105. Pfaff DW, Rapin I, Goldman S. Male predominance in autism: neuroendocrine influences on arousal and social anxiety. Autism Research 4(3):163-176 (June 2011).
  106. Estes A, Shaw DWW, Sparks BF, Friedman S, Giedd JN, Dawson G, Bryan M, Dager SR. Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder. Autism Research 4(3):212-220 (June 2011).
  107. Cheung C, McAlonan GM, Fung YY, Fung G, Yu KK, Tai K, Sham PC, Chua SE. MRI study of minor physical anomaly in childhood autism implicates aberrant neurodevelopment in infancy. PLoS ONE 6(6):e20246 (8 June 2011).
  108. McAleer P, Kay JW, Pollick FE, Rutherford MD. Intention perception in high functioning people with autism spectrum disorders using animacy displays derived from human actions. Journal of Autism and Developmental Disorders 41(8):1053-1063 (August 2011).
  109. Oldershaw A, Hambrook D, Rimes KA, Tchanturia K, Treasure J, Richards S, Schmidt U, Chalder T. Emotion recognition and emotional theory of mind in chronic fatigue syndrome. Psychology and Health 26(8):989-1005 (August 2011).
  110. Kunda M, Goel AK. Thinking in pictures as a cognitive account of autism. Journal of Autism and Developmental Disorders 41(9):1157-1177 (September 2011).
  111. Amr M, Raddad D, El-Mehesh F, Mahmoud EH, El-Gilany AH. Sex differences in Arab children with autism spectrum disorders. Research in Autism Spectrum Disorders 5(4):1343-1350 (October-December 2011).
  112. Izuma K, Matsumoto K, Camerer CF, Adolphs R. Insensitivity to social reputation in autism. Proceedings of The National Academy of Sciences of The United States of America 108(42):17302-17307 (18 October 2011).
  113. Kana RK, Libero LE, Moore MS. Disrupted cortical connectivity theory as an explanatory model for autism spectrum disorders. Physics of Life Reviews 8(4):410-437 (December 2011).
  114. Beacher FD, Minati L, Baron-Cohen S, Lombardo MV, Lai MC, Gray MA, Harrison NA, Critchley HD. Autism attenuates sex differences in brain structure: a combined voxel-based morphometry and diffusion tensor imaging study. American Journal of Neuroradiology 33(1):83-89 (January 2012).
  115. McKay LS, Simmons DR, McAleer P, Marjoram D, Piggot J, Pollick FE. Do distinct atypical cortical networks process biological motion information in adults with autism spectrum disorders? NeuroImage 59(2):1524-1533 (16 January 2012).
  116. Campbell BC, Wang SSH. Familial linkage between neuropsychiatric disorders and intellectual interests. PLoS ONE 7(1):e30405 (26 January 2012).
  117. Millan MJ, Agid Y, Brune M, Bullmore ET, Carter CS, Clayton NS, Connor R, Davis S, Deakin B, DeRubeis RJ, Dubois B, Geyer MA, Goodwin GM, Gorwood P, Jay TM, Joels M, Mansuy IM, Meyer-Lindenberg A, Murphy D, Rolls E, Saletu B, Spedding M, Sweeney J, Whittington M, Young LJ. Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nature Reviews Drug Discovery 11(2):141-168 (February 2012).
  118. Iidaka T, Miyakoshi M, Harada T, Nakai T. White matter connectivity between superior temporal sulcus and amygdala is associated with autistic trait in healthy humans. Neuroscience Letters 510(2):154-158 (29 February 2012).
  119. Emck C, Bosscher RJ, van Wieringen PCW, Doreleijers T, Beek PJ. Psychiatric symptoms in children with gross motor problems. Adapted Physical Activity Quarterly 29(2):161-178 (April 2012).
  120. Kishida KT, Li J, Schwind J, Montague PR. New approaches to investigating social gestures in autism spectrum disorder. Journal of Neurodevelopmental Disorders 4:14 (24 May 2012).
  121. Auyeung B, Knickmeyer R, Ashwin E, Taylor K, Hackett G, Baron-Cohen S. Effects of fetal testosterone on visuospatial ability. Archives of Sexual Behavior 41(3):571-581 (June 2012).
  122. Lai MC, Lombardo MV, Chakrabarti B, Ecker C, Sadek SA, Wheelwright SJ, Murphy DGM, Suckling J, Bullmore ET, Baron-Cohen S, MRC AIMS Consortium. Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults. NeuroImage 61(4):1347-1354 (16 July 2012).
  123. Ohta H, Yamada T, Watanabe H, Kanai C, Tanaka E, Ohno T, Takayama Y, Iwanami A, Kato N, Hashimoto R. An fMRI study of reduced perceptual load-dependent modulation of task-irrelevant activity in adults with autism spectrum conditions. NeuroImage 61(4):1176-1187 (16 July 2012).
  124. Dinstein I, Heeger DJ, Lorenzi L, Minshew NJ, Malach R, Behrmann M. Unreliable evoked responses in autism. Neuron 75(6):981-991 (20 September 2012).
  125. Pellicano E, Burr D. When the world becomes ‘too real’: a Bayesian explanation of autistic perception. Trends in Cognitive Sciences 16(10):504-510 (October 2012).
  126. Russell-Smith SN, Maybery MT, Bayliss DM, Sng AAH. Support for a link between the local processing bias and social deficits in autism: an investigation of embedded figures test performance in non-clinical individuals. Journal of Autism and Developmental Disorders 42(11):2420-2430 (November 2012).
  127. Zelena D. Vasopressin in health and disease with a focus on affective disorders. Central Nervous System Agents in Medicinal Chemistry 12(4):286-303 (December 2012).
  128. Kerns CM, Kendall PC. The presentation and classification of anxiety in Autism Spectrum Disorder. Clinical Psychology — Science and Practice 19(4):323-347 (December 2012).
  129. Sinderberry B, Brown S, Hammond P, Stevens AF, Schall U, Murphy DGM, Murphy KC, Campbell LE. Subtypes in 22q11.2 deletion syndrome associated with behaviour and neurofacial morphology. Research in Developmental Disabilities 34(1):116-125 (January 2013).
  130. Doyle-Thomas KAR, Duerden EG, Taylor MJ, Lerch JP, Soorya LV, Wang AT, Fan J, Hollander E, Anagnostou E. Effects of age and symptomatology on cortical thickness in autism spectrum disorders. Research in Autism Spectrum Disorders 7(1):141-150 (January-March 2013).

CITED IN MY OTHER PUBLICATIONS:

  1. Baron-Cohen S, Golan O, Chakrabarti B, Belmonte MK. Social cognition and autism spectrum conditions. In: Social Cognition and Developmental Psychopathology (C Sharp, P Fonagy, I Goodyer, eds.), pp 29-56. Oxford: Oxford University Press (4 September 2008).